Association between dipeptidyl peptidase-4 inhibitors use and leptin in type 2 diabetes mellitus

Diabetology & Metabolic Syndrome

Xin Wei¹  Zening Jin¹  Zhuo Wang²  Xiaohong Zheng³  Yu Bai⁴  Xin Liu⁵ 

[1] Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;Department of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;Department of Otolaryngology, Beijing Haidian Hospital, Beijing, China;Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;

关键词: Dipeptidyl peptidase-4 inhibitors;    Leptin;    Type 2 diabetes mellitus;    Randomized controlled trials;   

DOI  :  10.1186/s13098-021-00703-x

来源: Springer

【 摘 要 】

BackgroundDipeptidyl peptidase-4 inhibitors (DPP-4i) provide a unique antihyperglycemic effect by regulating incretin peptides in type 2 diabetes mellitus (T2DM) patients who are inadequately controlled with insulin therapy. The aim of this study was to investigate the impact of DPP-4i on leptin concentrations in subjects with T2DM.MethodsRandomized controlled trials (RCTs) with comparators were systematically searched through PubMed, Embase, and the Cochrane Library. Quantitative analysis was performed with a fixed or random-effects model according to heterogeneity. Publication bias was evaluated by using the standard methods for sensitivity analysis.ResultsTen trials with 698 patients with T2DM were included. Pooled analysis demonstrated that DPP-4i did not significantly change leptin concentrations (1.31 ng/mL, 95 % CI − 0.48 to 3.10). DPP-4i exerted effects on modulating leptin levels compared to active comparators (0.21 ng/mL, 95 % CI − 1.37 to 1.78). Meta-analysis was powerful and stable after sensitivity analysis.ConclusionsDPP-4i did not modulate leptin concentrations in T2DM and exerted no stronger effects than traditional antidiabetic agents.

【 授权许可】

CC BY