Insecticide resistance status of malaria vectors Anopheles gambiae (s.l.) of southwest Burkina Faso and residual efficacy of indoor residual spraying with microencapsulated pirimiphos-methyl insecticide

Parasites & Vectors

Alphonsine Amanan Koffi¹  Domonbabele François de Sales Hien²  Roch Kounbobr Dabiré²  Nicolas Moiroux³  Aristide Sawdetuo Hien⁴  Mahamadi Kientega⁴  Didier Alexandre Kaboré⁴  Dieudonné Diloma Soma⁵  Barnabas Zogo⁶  Cédric Pennetier⁶  Anicet Georges Ouédraogo⁷ 

[1] Institut Pierre Richet, Institut National de Santé Publique, Bouaké, Côte d’Ivoire;Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso;Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso;MIVEGEC, IRD, CNRS, Univ. Montpellier, Montpellier, France;Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso;Université Nazi Boni, BP 109, Bobo-Dioulasso, Burkina Faso;Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso;Université Nazi Boni, BP 109, Bobo-Dioulasso, Burkina Faso;MIVEGEC, IRD, CNRS, Univ. Montpellier, Montpellier, France;MIVEGEC, IRD, CNRS, Univ. Montpellier, Montpellier, France;Institut Pierre Richet, Institut National de Santé Publique, Bouaké, Côte d’Ivoire;Université Nazi Boni, BP 109, Bobo-Dioulasso, Burkina Faso;

关键词: Vector control;    Resistance;    Chemical analysis;    Burkina Faso;    IRS;   

DOI  :  10.1186/s13071-020-04563-8

来源: Springer

【 摘 要 】

BackgroundThe rapid spread of insecticide resistance in malaria vectors and the rebound in malaria cases observed recently in some endemic areas underscore the urgent need to evaluate and deploy new effective control interventions. A randomized control trial (RCT) was conducted with the aim to investigate the benefit of deploying complementary strategies, including indoor residual spraying (IRS) with pirimiphos-methyl in addition to long-lasting insecticidal nets (LLINs) in Diébougou, southwest Burkina Faso.MethodsWe measured the susceptibility of the Anopheles gambiae (s.l.) population from Diébougou to conventional insecticides. We further monitored the efficacy and residual activity of pirimiphos-methyl on both cement and mud walls using a laboratory susceptible strain (Kisumu) and the local An. gambiae (s.l.) population.ResultsAn. gambiae (s.l.) from Diébougou was resistant to DDT, pyrethroids (deltamethrin, permethrin and alphacypermethrin) and bendiocarb but showed susceptibility to organophosphates (pirimiphos-methyl and chlorpyrimiphos-methyl). A mixed-effect generalized linear model predicted that pirimiphos-methyl applied on cement or mud walls was effective for 210 days against the laboratory susceptible strain and 247 days against the local population. The residual efficacy of pirimiphos-methyl against the local population on walls made of mud was similar to that of cement (OR = 0.792, [0.55–1.12], Tukey’s test p-value = 0.19).ConclusionsIf data on malaria transmission and malaria cases (as measured trough the RCT) are consistent with data on residual activity of pirimiphos-methyl regardless of the type of wall, one round of IRS with pirimiphos-methyl would have the potential to control malaria in a context of multi-resistant An. gambiae (s.l.) for at least 7 months.

【 授权许可】

CC BY