期刊论文详细信息
BMC Ophthalmology
Relationship between structural and functional changes in glaucomatous eyes: a multifocal electroretinogram study
Kenji Ozawa1  Hiroki Tanaka1  Akira Sawada1  Kiyofumi Mochizuki1  Tetsuya Yamamoto1  Kyoko Ishida2  Takuma Ishihara3 
[1] Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Gifu, Japan;Department of Ophthalmology, Toho University Ohashi Medical Center, 2-22-36, Ohashi, Meguro-ku, 153-8515, Tokyo, Japan;Gifu University Hospital, Innovative and Clinical Research Promotion Center, 1-1 Yanagido, Gifu-shi, 501-1194, Gifu, Japan;
关键词: Multifocal electroretinography;    Optical coherence tomography;    Humphrey field analyzer;    Open angle glaucoma;   
DOI  :  10.1186/s12886-021-02061-8
来源: Springer
PDF
【 摘 要 】

BackgroundThe nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of mfERG elicited by a circular stimulus centered on the fovea was significantly reduced in eyes with glaucoma. The PhNR to B-wave ratio (PhNR/B) is the optimal measure of the PhNR. However, clinical superiority for evaluating glaucoma patients has not been determined between N/T and PhNR/B yet.MethodsFor morphological assessments, ganglion cell complex (GCC) in six regions and the average were measured by optical coherence tomography (OCT). For functional assessment, Humphrey visual fields (VF) with mean sensitivities (MT) and mfERG scans with parameters of N/T and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. Sixty-nine eyes of 44 glaucoma patients were included and correlations between mfERG parameters and OCT or VF parameters were evaluated.ResultsThe mean age of patients was 59.4 years. The mean deviation for all eyes obtained with the VF 30–2 and VF 10–2 was − 7.00 and − 6.31 dB, respectively. Significant correlations between GCC thickness or VF parameter and the N/T were found, especially in the inferior and inforotemporal retinal areas corresponding to superior and superonasal VF sectors (GCC vs N/T; coefficient = − 7.916 and − 7.857, and MT vs N/T; coefficient = − 4.302 and − 4.437, in the inferior and inforotemporal retinal areas, respectively, all p values < 0.05). However, similar associations were not obtained between mfPhNR/B and OCT or VF parameters. The mfPhNR/B only in the inferotemporal sector was significantly correlated with the average thickness of GCC (coefficient = 4.823, P = 0.012).ConclusionsThe N/T was correlated with GCC and VF in more numbers of measurement areas than the mfPhNR/B in the current study, however, a future study modifying the stimuli and amplitudes to obtain the spatial correspondence to OCT and VF measurement will be required to evaluate the value of mfERG.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO202109173409522ZK.pdf 1586KB PDF download
  文献评价指标  
  下载次数:9次 浏览次数:3次