A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease

Clinical Epigenetics

Wim Vanden Berghe¹  Luc F. Van Gaal²  An Verrijken²  Evelien Van Dijck³  Wim Van Hul³  Sara Diels³  Bruno Derudas⁴  Philippe Lefebvre⁴  Jose J. Ceron⁵  Asta Tvarijonaviciute⁵  Sven Francque⁶  Kris Laukens⁷  Bart Cuypers⁷ 

[1] Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium;Department of Endocrinology, Diabetology and Metabolic Disease, Antwerp University Hospital, Antwerp, Belgium;Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium;Department of Medical Genetics, University of Antwerp, Prins Boudewijnlaan 43, 2650, Edegem, Antwerp, Belgium;Inserm, CHU Lille, Pasteur Institute of Lille, University of Lille, Lille, France;Interdisciplinary Laboratory of Clinical Analysis INTERLAB-UMU, University of Murcia, Murcia, Spain;Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium;Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium;Molecular Parasitology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;Adrem Data Lab, Department of Computer Science, University of Antwerp, Antwerp, Belgium;

关键词: PON1;    NAFLD;    Obesity;    Genetics;    Methylation;    -Omics;    Integrative analysis;   

DOI  :  10.1186/s13148-021-01142-1

来源: Springer

【 授权许可】

CC BY