Hybrid membranes for the production of blood contacting surfaces: physicochemical, structural and biomechanical characterization

Biomaterials Research

Laura Iop¹  Carlo Zardin²  Martina Todesco³  Andrea Bagno³  Tiziana Palmosi⁴  Gino Gerosa⁴  Filippo Romanato⁵  Pietro Capaldo⁵ 

[1] Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padova, via Giustiniani 2, 35128, Padova, Italy;Department of Industrial Engineering, University of Padua, via Marzolo 9, 35131, Padova, Italy;Department of Industrial Engineering, University of Padua, via Marzolo 9, 35131, Padova, Italy;L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128, Padova, Italy;L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128, Padova, Italy;Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padova, via Giustiniani 2, 35128, Padova, Italy;L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128, Padova, Italy;Department of Physics and Astronomy ‘G. Galilei’, University of Padova, via Marzolo 8, 35131, Padova, Italy;CNR-INFM TASC IOM National Laboratory, S.S. 14 Km 163.5, 34012, Basovizza, Trieste, Italy;

关键词: Porcine pericardium;    Decellularization;    Hybrid membrane;    Blood contacting surface;    Total artificial heart.;   

DOI  :  10.1186/s40824-021-00227-5

来源: Springer

【 摘 要 】

BackgroundDue to the shortage of organs’ donors that limits biological heart transplantations, mechanical circulatory supports can be implanted in case of refractory end-stage heart failure to replace partially (Ventricular Assist Device, VAD) or completely (Total Artificial Heart, TAH) the cardiac function. The hemocompatibility of mechanical circulatory supports is a fundamental issue that has not yet been fully matched; it mostly depends on the nature of blood-contacting surfaces.MethodsIn order to obtain hemocompatible materials, a pool of hybrid membranes was fabricated by coupling a synthetic polymer (polycarbonate urethane, commercially available in two formulations) with a decellularized biological tissue (porcine pericardium). To test their potential suitability as candidate materials for realizing the blood-contacting surfaces of a novel artificial heart, hybrid membranes have been preliminarily characterized in terms of physicochemical, structural and mechanical properties.ResultsOur results ascertained that the hybrid membranes are properly stratified, thus allowing to expose their biological side to blood and their polymeric surface to the actuation system of the intended device. From the biomechanical point of view, the hybrid membranes can withstand deformations up to more than 70 % and stresses up to around 8 MPa.ConclusionsThe hybrid membranes are suitable for the construction of the ventricular chambers of innovative mechanical circulatory support devices.

【 授权许可】

CC BY