Guillain-Barré syndrome as the first presentation of human immunodeficiency virus infection

BMC Neurology

José Eduardo Serra¹  Gonçalo Cruz¹  Helena Alves¹  Eugenia Ferreira¹  José Saraiva da Cunha¹  Mariana Lopes¹  Bruno Silva²  Patrícia Marques² 

[1] Department of Infectious Diseases, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal;Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal;

关键词: Guillain-Barre Syndrome;    HIV;    Antiretroviral Therapy;   

DOI  :  10.1186/s12883-021-02350-1

来源: Springer

【 摘 要 】

AimAntiretroviral therapy (ART) development has reduced the severity of neurological complications of the human immunodeficiency virus (HIV), but they remain prevalent and need prompt recognition. Acute inflammatory demyelinating polyneuropathy (AIDP) is a rare complication of human immunodeficiency virus (HIV) infection that may appear at any stage of the disease. In this case, AIDP represents a late presentation of HIV infection.MethodsDescriptive study. Patient data were collected from their medical records and by health assessment interviews.ResultsWe report a case of a 52-year-old male with acute lower limb weakness. Given the suggestive clinical presentation of AIDP and a positive HIV test, intravenous immunoglobulin (IVIG) was administered along with antiretroviral therapy. Progressive weakness to the upper limbs, autonomic dysfunction, and pain was observed. The second regimen of IVIG plus corticosteroids was administered. Muscle strength improved after three weeks.ConclusionsScreening for HIV in a patient with AIDP may provide a better outcome because of the early start of ART with good central nervous system penetration in HIV-infected patients.

【 授权许可】

CC BY