Noncoding RNAs involved in the STAT3 pathway in glioma

Cancer Cell International

Bin Xu¹  Zhengyuan Huo¹  Xiaolu Zhang¹  Zheng Bian¹  Wei Ji¹  Jiantong Jiao¹  Junfei Shao¹  Hui Huang¹  Jin Huang¹ 

[1] Department of Neurosurgery, Wuxi People’s Hospital of Nanjing Medical University, Wuxi, People’s Republic of China;

关键词: glioma;    miRNA;    lncRNAs;    circRNAs;    STAT3;   

DOI  :  10.1186/s12935-021-02144-y

来源: Springer

【 摘 要 】

Glioma is the most common malignant primary brain tumour in adults. Despite improvements in neurosurgery and radiotherapy, the prognosis of glioma patients remains poor. One of the main limitations is that there are no proper clinical therapeutic targets for glioma. Therefore, it is crucial to find one or more effective targets. Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT family of genes. Abnormal expression of STAT3 is involved in the process of cell proliferation, migration, invasion, immunosuppression, angiogenesis, dryness maintenance, and resistance to radiotherapy and chemotherapy in glioma. Therefore, STAT3 has been considered an ideal therapeutic target in glioma. Noncoding RNAs (ncRNAs) are a group of genes with limited or no protein-coding capacity that can regulate gene expression at the epigenetic, transcriptional and posttranscriptional level. In this review, we summarized the ncRNAs that are correlated with the ectopic expression of STAT3 in glioma.

【 授权许可】

CC BY