Prenatal and postnatal exposure to Bisphenol A and Asthma: a systemic review and meta-analysis

Journal of Thoracic Disease

article

Mindan Wu¹  Yinfang Wu¹  Shiyi Yang¹  Qichuan Zhang²  Huahao Shen¹  Shuyi Wang⁴  Qingyu Weng¹  Haixia Chen¹  Jiaxin Shen¹  Zhouyang Li¹  Yanping Wu¹  Yun Zhao¹  Miao Li¹ 

[1] Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital ofZhejiang University School of Medicine;Department of Respiration, Shantou Central Hospital, Affiliated Shantou Hospital ofSun Yat-sen University;State Key Laboratory for RespiratoryDiseases;School of Public Health, Sun Yet-sen University;4State Key Laboratory for RespiratoryDiseases

关键词: Bisphenol A (BPA);    asthma;    wheeze;    children;    meta-analysis;   

DOI  :  10.21037/jtd-20-1550

学科分类：呼吸医学

来源: Pioneer Bioscience Publishing Company

【 摘 要 】

Background: Bisphenol A (BPA) is a plasticizer with high production and ubiquitous usage in polycarbonate plastics and epoxy resins. The association between prenatal or postnatal exposure to BPA and childhood wheeze/asthma has not been well established. Our study aimed to provide further justification for the current studies. Methods: Studies were searched from PubMed, Web of Science, Scopus and Embase from inception until Sep 15, 2020. Meta-analysis was performed to calculate pooled adjusted odds ratios (aOR). The methodological quality of included studies was assessed by using the Newcastle Ottawa Scale (NOS). Results: Of 2,814 screened articles, 9 studies with 3,885 participants were included in the final analysis. When all studies were pooled, postnatal exposure to BPA was associated with a higher risk of childhood asthma (aOR =1.43; 95% CI: 1.28–1.59) or childhood wheeze (aOR =1.38; 95% CI: 1.18–1.62). Prenatal exposure to BPA had a small but significant increased risk of childhood asthma (aOR =1.17; 95% CI: 1.01–1.34). An increased risk of childhood wheeze was related to prenatal exposure to BPA at 16 weeks’ gestation (aOR =1.29; 95% CI: 1.07–1.55), but not at 26 weeks’ gestation (aOR =1.07; 95% CI: 0.88–1.29) nor at random-time gestation (aOR =1.02; 95% CI: 0.89–1.16). Conclusions: Prenatal and postnatal exposure to BPA was related to an increased risk of childhood asthma. However, only postnatal and early gestational exposure (at 16 weeks) to BPA could induce the risk of childhood wheeze, but not late gestational exposure (at 26 weeks).

【 授权许可】

Unknown