Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective

Frontiers in Pediatrics

article

Michiel A. G. E. Bannier¹  Philippe P. R. Rosias²  Quirijn Jöbsis¹  Edward Dompeling¹ 

[1] Department of Pediatric Respiratory Medicine, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Center;Department of Pediatrics, Zuyderland Medical Center

关键词: asthma;    wheeze;    exhaled breath condensate;    exhaled breath;    children;   

DOI  :  10.3389/fped.2019.00150

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.

【 授权许可】

CC BY