A novel wireless optical technique for quantitative evaluation of cerebral perfusion pressure in a fluid percussion animal model of traumatic brain injury

Quantitative Imaging in Medicine and Surgery

article

Yao-Kuang Huang¹  Chin-Kuo Lin³  Che-Chuan Wang⁴  Jinn-Rung Kuo⁴  Chien-Fu Lai⁵  Chien-Wei Chen¹  Bor-Shyh Lin⁵ 

[1] Division of Cardiovascular Surgery and Radiology, Chiayi Chang Gung Memorial Hospital;College of Medicine, Chang Gung University;Division of Pulmonary Infection and Critical Care, Department of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital;Division of Neurosurgery, Department of Surgery, Chi Mei Medical Center;Institute of Imaging and Biomedical Photonics, National Yang Ming Chiao Tung University

关键词: Near-infrared spectroscopy (NIRS);    oxy-hemoglobin (HbO 2 );    deoxy-hemoglobin;    total-hemoglobin (HbT);    cerebral perfusion pressure (CPP);    traumatic brain injury (TBI);   

DOI  :  10.21037/qims-20-777

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Background: Cerebral perfusion pressure (CPP) calculated by mean arterial pressure (MAP) minus intracranial pressure (ICP) is related to blood flow into the brain and reflects cerebral ischemia and oxygenation indirectly. Near-infrared spectroscopy (NIRS) can assess cerebral ischemia and hypoxia noninvasively and has been widely used in neuroscience. However, the correlation between CPP and NIRS, and its potential application in traumatic brain injury, has seldom been investigated. Methods: We used a novel wireless NIRS system and commercial ICP and MAP devices to assess the trauma to rat brains using different impact intensity. The relationship between CPP and NIRS parameters with increasing impact strength were investigated. Results: The results showed that changes in CPP (∆CPP), oxy-hemoglobin {∆[HbO2]}, total-hemoglobin {∆[HbT]}, and deoxy-hemoglobin were inversely proportional to the increase in impact intensity, and the correlations between ∆CPP, NIRS parameters {∆[HbO2], and ∆[HbT]} were significant. Conclusions: The NIRS system can assess cerebral ischemia and oxygenation non-invasively and changes of HbO2 and HbT may be used as reference parameters to assess the level of CPP in an animal model of traumatic brain injury.

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