Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case–control study

Journal of Translational Medicine

David M Patrick⁷  Patrick Tang⁷  Jennifer Gardy⁷  Shoshana Parker⁵  Theodore Steiner¹  Cristiane Yamabayashi⁶  Andre Mattman²  W Darlene Reid³  Ruth R Miller⁴ 

[1] Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver V5Z 3J5, BC, Canada;Adult Metabolic Disease Clinic, Vancouver General Hospital, Level 4, 2775 Laurel Street, Vancouver V5Z 1M9, BC, Canada;Department of Physical Therapy, University of Toronto, 160-500 University Avenue, Toronto M5G 1V7, ON, Canada;School of Population and Public Health, British Columbia Centre for Disease Control, University of British Columbia, 655 West 12th Avenue, Vancouver V5Z 4R4, BC, Canada;Centre for Health Evaluation and Outcome Sciences, 588-1081 Burrard Street, Vancouver V6Z 1Y6, BC, Canada;Muscle Biophysics Laboratory, Department of Physical Therapy, University of British Columbia, 828 West 10th Avenue, Vancouver V5Z 3P1, BC, Canada;British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver V5Z 4R4, BC, Canada

关键词: Tissue oxygen utilization;    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS);    Near-infrared spectroscopy (NIRS);   

Others  :  1212319
DOI  :  10.1186/s12967-015-0527-8

 received in 2015-03-26, accepted in 2015-05-09,  发布年份 2015

【 摘 要 】

Background

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness. Symptoms include profound fatigue and distinctive post-exertional malaise (PEM). We asked whether a submaximal exercise test would prove useful for identifying different patterns of tissue oxygen utilization in individuals with ME/CFS versus healthy subjects. Such a test has potential to aid with ME/CFS diagnosis, or to characterize patients’ illness.

Methods

A case–control study of 16 patients with ME/CFS compared to 16 healthy controls completing a 3-min handgrip protocol was performed. Response was measured using near-infrared spectroscopy, resulting in measurements of oxygenated (O₂Hb) and deoxygenated hemoglobin (HHb) over wrist extensors and flexors. Changes in O₂Hb (delta (d)O₂Hb) and HHb (dHHb) absorbance between the first and last contraction were calculated, as were the force–time product of all contractions, measured as tension-time index (TTI), and ratings of perceived exertion (RPE).

Results

Individuals with ME/CFS demonstrated smaller dO₂Hb and dHHb than controls. However, after adjusting for TTI and change in total hemoglobin (delta (d)tHb), differences in dO₂Hb and dHHb were reduced, with large overlapping variances. RPE was significantly higher for cases than controls, particularly at rest.

Conclusions

Relative to controls, participants with ME/CFS demonstrated higher RPE, lower TTI, and reduced dO₂Hb and dHHb during repetitive handgrip exercise, although considerable variance was observed. With further study, submaximal exercise testing may prove useful for stratifying patients with a lower propensity for inducing PEM, and have the ability to establish baseline intensities for exercise prescription.

【 授权许可】

   
2015 Miller et al.

【 图 表 】

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