Suckling by Schistosoma mansoni-infected mothers restored IgG2a and TGF-β production, but not IL-6 and delayed-type hypersensitivity in IL-12/IL-23-deficient mice

Sociedade Brasileira de Medicina Tropical. Revista

article

Fabiana Leticia da Silva¹  Maria da Conceição Silva²  Gabriela Calixto Ribeiro de Holanda²  Eridan de Medeiros Coutinho¹  Silvia Maria Lucena Montenegro¹  Clarice Neuenschwander Lins de Morais¹  Valdênia Maria Oliveira de Souza³ 

[1] Instituto Aggeu Magalhães, Laboratório de Imunopatologia e Biologia Molecular;Universidade Federal de Pernambuco, Laboratório de Imunopatologia Keizo Asami;Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas

关键词: Schistosomiasis mansoni;    Suckling;    Hypersensitivity;   

DOI  :  10.1590/0037-8682-0744-2020

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Introduction: Suckling by schistosomotic mice improves anti-ovalbumin (OA) antibody production, while delayed-type hypersensitivity (DTH) remains unaffected. This property of milk from schistosomotic mice was investigated in IL-12/IL-23-deficient mice (IL-12p40KO). Methods: We compared anti-OA DTH, IgG2a and cytokines in wild-type and IL-12p40KO mice suckled by infected (SIM) or non-infected (CONTROL) mothers. Results: SIM mice showed similar intensity and eosinophils in the DTH, which was abolished in IL-12p40KO and IL-12p40KO-SIM mice. In IL-12p40KO-SIM, IgG2a and TGF-β levels were higher, but IL-6 levels were lower. Conclusions: Milk from schistosomotic mothers may evoke IgG2a without eliciting DTH in IL-12/IL-23 deficiencies, by changing TGF-β/IL-6 levels.

【 授权许可】

CC BY