Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil

Sociedade Brasileira de Medicina Tropical. Revista

article

Alejandro Marcel Hasslocher-Moreno¹  Roberto Magalhaes Saraiva¹  Pedro Emmanuel Alvarenga Americano do Brasil¹  Luiz Henrique Conde Sangenis¹  Sergio Salles Xavier¹  Andréa Silvestre de Sousa²  Gilberto Marcelo Sperandio-da-Silva¹  Fernanda de Souza Nogueira Sardinha Mendes¹  Andréa Rodrigues da Costa¹  Marcelo Teixeira de Holanda¹  Henrique Horta Veloso¹  Flavia Mazzoli-Rocha¹  Fernanda Martins Carneiro¹  Luciana Fernandes Portela¹  Mauro Felippe Felix Mediano¹ 

[1] Instituto Nacional de Infectologia Evandro Chagas;Instituto Nacional de Infectologia Evandro Chagas, Brasil. Universidade Federal do Rio de Janeiro

关键词: Chagas disease;    Epidemiologic studies;    Cohort studies;   

DOI  :  10.1590/0037-8682-0040-2021

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Introduction: We aimed to describe the sociodemographic, epidemiological, and clinical characteristics of patients with chronic Chagas disease (CD) at an infectious disease referral center. Changes in patient profiles over time were also evaluated. Methods: This retrospective study included patients with CD from November 1986–December 2019. All patients underwent an evaluation protocol that included sociodemographic profile; epidemiological history; anamnesis; and physical, cardiologic, and digestive examinations. Trend differences for each 5-year period from 1986 to 2019 were tested using a nonparametric trend test for continuous and generalized linear models with binomial distribution for categorical variables. Results: A total of 2,168 patients (52.2% women) were included, with a mean age of 47.8 years old. White patients with low levels of education predominated. The reported transmission mode was vectorial in 90.2% of cases. The majority came from areas with a high prevalence (52.2%) and morbidity (67.8%) of CD. The most common clinical presentation was the indeterminate form (44.9%). The number of patients referred gradually decreased and the age at admission increased during the study period, as did the patients’ levels of education. Conclusions: The clinical profile of CD is characterized by a predominance of the indeterminate form of the disease. Regarding the patients who were followed up at the referral center, there was a progressive increase in the mean age and a concomitant decrease in the number of new patients. This reflects the successful control of vector and transfusion transmission in Brazil as well as the aging population of patients with CD.

【 授权许可】

CC BY