Genomics and functional genomics in Leishmania and Trypanosoma cruzi: statuses, challenges and perspectives

Memorias do Instituto Oswaldo Cruz

article

Daniella C Bartholomeu¹  Santuza Maria Ribeiro Teixeira²  Angela Kaysel Cruz³ 

[1] Universidade Federal de Minas Gerais, Departamento de Parasitologia;Universidade Federal de Minas Gerais, Departamento de Bioquímica e Imunologia;Universidade de São Paulo, Departamento de Biologia Celular e Molecular

关键词: Leishmania;    Trypanosoma cruzi;    genomics;    transcriptomics;    functional genomics;   

DOI  :  10.1590/0074-02760200634

学科分类：地质学

来源: Bioline International

【 摘 要 】

The availability of Trypanosomatid genomic data in public databases has opened myriad experimental possibilities that have contributed to a more comprehensive understanding of the biology of these parasites and their interactions with hosts. In this review, after brief remarks on the history of the Trypanosoma cruzi and Leishmania genome initiatives, we present an overview of the relevant contributions of genomics, transcriptomics and functional genomics, discussing the primary obstacles, challenges, relevant achievements and future perspectives of these technologies.

【 授权许可】

Free