Journal of venomous animals and toxins | |
Neutrophils activated by BJcuL, a C-type lectin isolated from Bothrops jararacussu venom, decrease the invasion potential of neuroblastoma SK-N-SH cells in vitro | |
article | |
Jessica Ohana Lemes Carneiro-Goetten1  Bruna Santos Rodrigues2  Rodrigo Amauri Nogoceke2  Thatyanne Gradowski do Nascimento1  Andrea Novais Moreno-Amaral1  Patricia Maria Stuelp-Campelo2  Selene Elifio-Esposito2  | |
[1] Programa de Pós-graduação em Ciências da Saúde, PontifíciaUniversidade Católica do Paraná (PUCPR);Pontifícia Universidade Católica doParaná (PUCPR) | |
关键词: Snake venom; Neuroblastoma; SK-N-SH cells; C-type lectin; Polymorphonuclear leukocyte; Neoplasm invasion; | |
DOI : 10.1590/1678-9199-JVATITD-2019-0073 | |
学科分类:药理学 | |
来源: BioMed Central | |
【 摘 要 】
Background: Neuroblastoma is a pediatric tumor with a mortality rate of 40% in the most aggressive cases. Tumor microenvironment components as immune cells contribute to the tumor progression; thereby, the modulation of immune cells to a pro-inflammatory and antitumoral profile could potentialize the immunotherapy, a suggested approach for high-risk patients. Preview studies showed the antitumoral potential of BJcuL, a C- type lectin isolated from Bothrops jararacussu venom. It was able to induce immunomodulatory responses, promoting the rolling and adhesion of leukocytes and the activation of neutrophils.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202108200002996ZK.pdf | 1200KB | download |