Neutrophils activated by BJcuL, a C-type lectin isolated from Bothrops jararacussu venom, decrease the invasion potential of neuroblastoma SK-N-SH cells in vitro

Journal of venomous animals and toxins

article

Jessica Ohana Lemes Carneiro-Goetten¹  Bruna Santos Rodrigues²  Rodrigo Amauri Nogoceke²  Thatyanne Gradowski do Nascimento¹  Andrea Novais Moreno-Amaral¹  Patricia Maria Stuelp-Campelo²  Selene Elifio-Esposito² 

[1] Programa de Pós-graduação em Ciências da Saúde, PontifíciaUniversidade Católica do Paraná (PUCPR);Pontifícia Universidade Católica doParaná (PUCPR)

关键词: Snake venom;    Neuroblastoma;    SK-N-SH cells;    C-type lectin;    Polymorphonuclear leukocyte;    Neoplasm invasion;   

DOI  :  10.1590/1678-9199-JVATITD-2019-0073

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background: Neuroblastoma is a pediatric tumor with a mortality rate of 40% in the most aggressive cases. Tumor microenvironment components as immune cells contribute to the tumor progression; thereby, the modulation of immune cells to a pro-inflammatory and antitumoral profile could potentialize the immunotherapy, a suggested approach for high-risk patients. Preview studies showed the antitumoral potential of BJcuL, a C- type lectin isolated from Bothrops jararacussu venom. It was able to induce immunomodulatory responses, promoting the rolling and adhesion of leukocytes and the activation of neutrophils.

【 授权许可】

CC BY