The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review

Frontiers in Cardiovascular Medicine

article

Lavinia Rech¹  Peter P. Rainer¹ 

[1] Division of Cardiology, Department of Internal Medicine, Medical University of Graz

关键词: STING;    interferon;    DAMPs;    cardiovascular;    inflammation;    cGAS;   

DOI  :  10.3389/fcvm.2021.715903

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. Recent studies show that also self-DNA may activate cGAS-STING, for instance, DNA released from nuclei or mitochondria during obesity or myocardial infarction. Here, we focus on emerging evidence describing the interaction of cGAS-STING with cardiovascular risk factors and disease. We also touch on translational therapeutic opportunities and potential further investigations.

【 授权许可】

CC BY