Relevance of Multi-Omics Studies in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine

article

Paola Leon-Mimila¹  Jessica Wang¹  Adriana Huertas-Vazquez¹ 

[1] Division of Cardiology, David Geffen School of Medicine, Department of Medicine, University of California

关键词: multi-omics;    cardiovascular disease;    heart disease;    systems biology;    data integration;   

DOI  :  10.3389/fcvm.2019.00091

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Cardiovascular diseases are the leading cause of death around the world. Despite the larger number of genes and loci identified, the precise mechanisms by which these genes influence risk of cardiovascular disease is not well understood. Recent advances in the development and optimization of high-throughput technologies for the generation of “omics data” have provided a deeper understanding of the processes and dynamic interactions involved in human diseases. However, the integrative analysis of “omics” data is not straightforward and represents several logistic and computational challenges. In spite of these difficulties, several studies have successfully applied integrative genomics approaches for the investigation of novel mechanisms and plasma biomarkers involved in cardiovascular diseases. In this review, we summarized recent studies aimed to understand the molecular framework of these diseases using multi-omics data from mice and humans. We discuss examples of omics studies for cardiovascular diseases focused on the integration of genomics, epigenomics, transcriptomics, and proteomics. This review also describes current gaps in the study of complex diseases using systems genetics approaches as well as potential limitations and future directions of this emerging field.

【 授权许可】

CC BY