Editorial: Hemostatic Challenges in Pediatric Critical Care Medicine

Frontiers in Pediatrics

article

Gemma L. Crighton¹  Oliver Karam²  Marianne E. Nellis³  Simon J. Stanworth⁴ 

[1] Department of Haematology, Royal Children's Hospital;Division of Pediatric Critical Care Medicine, Children's Hospital of Richmond at VCU Richmond, United States;Division of Pediatric Critical Care Medicine, NY Presbyterian Hospital—Weill Cornell Medicine, United States;NHS Blood and Transplant;Oxford University Hospitals NHS Foundation Trust;Radcliffe Department of Medicine and Oxford BRC Haematology Theme, University of Oxford, United Kingdom

关键词: pediatric;    critical care;    haemostasis;    coagulation;    bleeding;    transfusion;    hemorrhage;   

DOI  :  10.3389/fped.2021.697921

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

“When one thinks about the current state of critical care for children, do we not wonder why and how we got here, how we are doing, and where we are going?” (John J. Downes—US pediatric intensivist). How we got here? Hemostasis (derived from Greek haimostasis) literally means arrest of bleeding (1). Our knowledge of hemostasis has greatly advanced since ancient Greek times, when Homer described in The Iliad and The Odyssey, the treatment of war wounds with compression, bandages, cautery and styptics (2). Hemostasis is a complex and highly regulated process, involving the vascular system, platelets, coagulation factors, fibrinolytic systems, serine protease, kinin, and complement systems (3). This finely balanced system functions effectively to protect against both bleeding and thrombotic complications.

【 授权许可】

CC BY