The Relationship Between Indicators of Nasal Respiratory Function and Spirometric Parameters in Children With Bronchial Asthma

Frontiers in Pediatrics

article

Svetlana V. Krasilnikova¹  Alexey A. Khramov²  Regina N. Khramova²  Dmitry Yu. Ovsyannikov³  Mojisola I. Daniel-Abu³  Alexey Novozhilov⁴  Andrey V. Shahov¹  Nailya I. Kubysheva⁵  Tatyana I. Eliseeva² 

[1] Department of ENT Diseases, Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation;Department of Hospital Pediatrics, Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation;Department of Pediatrics, Peoples' Friendship University of Russia;ENT-Department, Volga District Medical Center Federal Medical-Biological Agency Russia;Clinical Linguistics Laboratory, Kazan Federal University

关键词: bronchial asthma;    allergic rhinitis;    rhinomanometry;    spirometry;    children;   

DOI  :  10.3389/fped.2020.580043

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Introduction: The relationship between objective indicators of nasal obstruction and airflow limitation in children with bronchial asthma (BA) and allergic rhinitis (AR) has not yet been studied. Objective: To study the relationship between objective parameters of nasal obstruction and airflow limitation, determined using the methods of anterior active rhinomanometry (AARM) and spirometry in children with BA and AR. Materials and Methods: Eighty eight children and adolescents with BA and AR, boys−65.9% (58/88), were examined. The median age was 11.09 [10.42; 11.76] years. To determine airflow limitation, the following spirometric parameters were evaluated: forced vital capacity of the lungs (FVC), forced expiratory volume in 1 s (FEV 1 ), the ratio of FEV 1 /FVC, and maximum expiratory flow at the point 25% of the flow-volume loop (MEF 25 ). Data were recorded both in absolute values and in relative units (% pred). Nasal respiratory function was determined by AARM based on the total nasal airflow (TNAF) in absolute (Pa/cm 3 /s) and relative units (RTNAF, % pred). Results: In the general cohort and in boys but not in girls, a statistically significant direct correlation was found between TNAF (Pa/cm 3 /s) and absolute spirometry parameters of bronchial patency—all had p 0.05. Additional analysis of literature was conducted to ascertain that the identified gender differences were not occasional. Conclusion: The significant positive correlation of absolute values of AARM and spirometric parameters in children with BA and AR was established, which apparently reflects the physical development of children. Of all the relative indicators of spirometry, only MEF 25 (% pred), which indirectly reflects the patency of small bronchi, had a distinct direct correlation with RTNAF. These patterns are clearly expressed in boys with BA. In girls with this disease, however, the relationship between nasal respiratory function and spirometric indicators seems to be more complex and requires further study.

【 授权许可】

CC BY