Prevalence and Management of Severe Hand, Foot, and Mouth Disease in Xiangyang, China, From 2008 to 2013

Frontiers in Pediatrics

article

Jian Liu¹  Jing Qi³ 

[1] Department of Pediatrics, The Second School of Clinical Medicine, Affiliated Baoan Hospital of Shenzhen, Southern Medical University;Department of Pediatrics, The Second Affiliated Hospital of Shenzhen University;Department of Neurology, Affiliated Baoan Hospital of Shenzhen, Southern Medical University

关键词: hand;    foot;    mouth disease;    human enterovirus 71;    coxsackievirus A16;    lung-protective ventilation;    contagious disease;   

DOI  :  10.3389/fped.2020.00323

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Therapeutic strategies for severe hand, foot, and mouth disease (HFMD) are currently either inconsequent or deficient in evidence. We retrospectively surveyed HFMD outbreaks in Xiangyang from June 2008 to December 2013. HFMD is staged from I to V according to clinical severity. Severe HFMD is defined as a case involving the central nervous system (CNS). We analyzed risk factors for fatality of severe cases and compared the efficiency and outcome of some therapies by binary logistic regression. The overall HFMD cases included 637 (1.26%) severe cases and 38 fatalities (0.075%). Analyses indicate that age (40 mg/L), and cardiac troponin I (>0.04 ng/ml) are risk factors for fatality (all P 0.05). Precise recognition of the severe HFMD cases in early stage IV and prompt IVIG and mechanical ventilation application may reduce mortality. Mechanical ventilation training programs and dispatch of specialists to hospitals where there is no chance of transferring critical cases to the severe HFMD designated hospitals are two key measures to reduce fatality.

【 授权许可】

CC BY