期刊论文详细信息
Frontiers in Pediatrics
Human Endogenous Retroviruses Are Preferentially Expressed in Mononuclear Cells From Cord Blood Than From Maternal Blood and in the Fetal Part of Placenta
article
Massimiliano Bergallo1  Pier Angelo Tovo1  Luca Marozio2  Giovanni Botta3  Annalisa Tancredi2  Valentina Daprà1  Ilaria Galliano1  Paola Montanari1  Alessandra Coscia4  Chiara Benedetto2 
[1] Pediatric Laboratory, Department of Pediatric Sciences and Public Health, University of Turin;Department of Surgical Sciences, University of Turin;Department of Pathology AOU Città della Salute e della Scienza di Torino;Neonatology Unit, Department of Pediatric Sciences and Public Health, University of Turin
关键词: HERV human endogenous retroviruses;    PCR;    placenta;    cord blood;    mRNA expression;   
DOI  :  10.3389/fped.2020.00244
学科分类:社会科学、人文和艺术(综合)
来源: Frontiers
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【 摘 要 】

Background: Placenta shows high transcription levels of human endogenous retroviruses (HERVs) that are overexpressed during embryonic and fetal development. Methods: In order to gather further information on the degree of HERV activation in maternal and fetal tissues we assessed the transcription levels of pol genes of HERV-H, -K, and -W in PBMCs of newborns and their mothers as well as in chorion (fetal part) and decidua basalis (maternal part) of the placenta using a real time PCR assay. Results: Transcripts of pol genes of the three HERV families were significantly higher in mononuclear cells from cord blood than from maternal blood and in the fetal part than in the maternal part of the placenta. Conclusions: The HERV over-expressions in cells and tissues of the offspring are further clues that they play pivotal physiologic roles during early life events and suggest that HERV-driven abnormalities of pregnancy and fetal development may derive mostly from the conceptus, not from the mother.

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