Application of Neurally Adjusted Ventilatory Assist in Premature Neonates Less Than 1,500 Grams With Established or Evolving Bronchopulmonary Dysplasia

Frontiers in Pediatrics

article

Xiao Rong¹  Rui-Lian Guan¹  Yi Sun¹  Huayan Zhang²  Feng Liang¹  Yuan-Jing Li¹  Hong Liang¹  Xiao-Peng Zhao¹  Hong-Mei Zou¹  Wei-Neng Lu¹  Hui Shi¹  Jing-Hua Zhang¹ 

[1] Division of Neonatology, Guangzhou Women and Children's Medical Center Affiliated With Jinan University;Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, United States

关键词: premature infants;    bronchopulmonary dysplasia;    BPD;    neurally adjusted ventilatory assist ventilation;    NAVA;    very low birth weight;    VLBW;    mechanical ventilation;   

DOI  :  10.3389/fped.2020.00110

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Very low birth weight premature (VLBW) infants with bronchopulmonary dysplasia (BPD) often need prolonged respiratory support, which is associated with worse outcomes. The application of neurally adjusted ventilatory assist ventilation (NAVA) in infants with BPD has rarely been reported. This study investigated whether NAVA is safe and can reduce the duration respiratory support in VLBW premature infants with established or evolving BPD. Methods: This retrospective matched-cohort study included patients admitted to our NICU between April 2017 to April 2019 who were born at 0.05). However, NAVA was well tolerated and there was a decrease in the need of sedation ( p = 0.012) after switching to NAVA. Conclusion: NAVA, when used as a sequel mode of ventilation, in premature neonates <1,500 g with evolving or established BPD showed a similar effect compared to conventional ventilation in respiratory outcomes. NAVA can be safely used in this patient population and potentially can decrease the need of sedation.

【 授权许可】

CC BY