Reduced 24-h Sodium Excretion Is Associated With a Disturbed Plasma Acylcarnitine Profile in Vasovagal Syncope Children: A Pilot Study

Frontiers in Pediatrics

article

Jinqing Song¹  Chunyan Tao¹  Guozhen Chen²  Selena Chen³  Wenrui Xu¹  Junbao Du¹  Yanling Yang¹  Yaqian Huang¹ 

[1] Department of Pediatrics, Peking University First Hospital;Department of Pediatrics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University;Division of Biological Sciences, University of California, United States

关键词: carnitine;    acylcarnitine;    low sodium intake;    vasovagal syncope;    children;   

DOI  :  10.3389/fped.2020.00098

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective: To investigate if the low sodium intake is associated with the plasma carnitine and acylcarnitine profile in children with vasovagal syncope (VVS). Materials and Methods: Twenty-six children suffering from VVS were recruited in the present study and divided into a group of low urinary sodium excretion or a group of normal urinary sodium excretion according to the excretion of 24-h urinary sodium 0.05). Concentrations of plasma tiglylcarnitine (C5:1), hydroxyhexadecanoylcarnitine (C16OH), hydroxyoctadecanoylcarnitine (C18OH), and carnitine C22 were significantly higher in the group of low urinary sodium excretion than in the group of normal urinary sodium excretion (all p- values = 0.048); moreover, they were all negatively correlated with 24-h urinary sodium levels (all p -values = 0.016). There were no differences between the two groups in other acylcarnitines or free carnitine. Conclusions: Reduced excretion of 24-h urinary sodium is associated with a disturbed plasma acylcarnitine profile in children with VVS. The findings suggest that restricted sodium intake-induced disturbance of plasma acylcarnitines and related cellular energy metabolism might be involved in the pathogenesis of VVS in children.

【 授权许可】

CC BY