Metabolites | |
Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration | |
Sudeepa Bhattacharyya2  Lisa Pence5  Richard Beger5  Shubhra Chaudhuri2  Sandra McCullough2  Ke Yan4  Pippa Simpson4  Leah Hennings3  Jack Hinson1  | |
[1] Departments of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; E-Mail:;Departments of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA; E-Mails:;Departments of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; E-Mail:;Medical College of Wisconsin, Milwaukee, WI 53226, USA; E-Mails:;Division of Systems Biology, National Center for Toxicological Research, Jefferson, AR 72079, USA; E-Mails: | |
关键词: acetaminophen; hepatic; β-oxidation; toxicity; acylcarnitine; | |
DOI : 10.3390/metabo3030606 | |
来源: mdpi | |
【 摘 要 】
High doses of acetaminophen (APAP) result in hepatotoxicity that involves metabolic activation of the parent compound, covalent binding of the reactive intermediate
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190034519ZK.pdf | 644KB | download |