Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature

Frontiers in Medicine

article

Nicola Veronese¹  Liye Zou²  Mark A. Tully³  Petre Cristian Ilie⁴  Mike Trott⁵  Guillermo F. López-Sánchez⁶  Lee Smith⁵  Jacopo Demurtas⁷  Lin Yang⁹  Roberto Tonelli⁷  Mario Barbagallo¹  Pierluigi Lopalco^1,12  Erik Lagolio^1,13  Stefano Celotto^1,14  Damiano Pizzol^1,15 

[1] Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo;Exercise and Mental Health Laboratory, Shenzhen University;School of Health Sciences, Institute of Mental Health Sciences, Ulster University, United Kingdom;Research and Innovation Department, The Queen Elizabeth Hospital Foundation Trust, United Kingdom;The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, United Kingdom;Faculty of Sport Sciences, University of Murcia;Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia;Primary Care Department;Department of Cancer Epidemiology and Prevention Research, Alberta Health Services;Departments of Oncology and Community Health Sciences, University of Calgary;Respiratory Intensive Care Unit, University Hospital of Modena;Department Translational Research and New Technologies in Medicine and Surgery, University of Pisa;Emergency Medicine (A&E) - Asl2 - H Santa Corona;Primary Care Department, Azienda Sanitaria Universitaria Friuli Centrale;Italian Agency for Development Cooperation

关键词: COVID-19;    coronavirus;    corticosteroids;    methylprednisolone;    pneumonia;    ARDS;    SARS-Cov-2;   

DOI  :  10.3389/fmed.2020.00170

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines. Patients with a validated diagnosis of COVID-19 and using corticosteroids were included, considering all health outcomes. Four studies with 542 Chinese participants were included. Two studies reported negative findings regarding the use of corticosteroids in patients with COVID-19, i.e., corticosteroids had a detrimental impact on clinical outcomes. One study reported no significant association between the use of corticosteroids and clinical outcomes. However, one study, on 201 participants with different stages of pneumonia due to COVID-19, found that in more severe forms, the administration of methylprednisolone significantly reduced the risk of death by 62%. The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition.

【 授权许可】

CC BY