Encrusted Uropathy: A Comprehensive Overview—To the Bottom of the Crust

Frontiers in Medicine

article

Els Van de Perre¹  Gina Reichman²  Deborah De Geyter³  Caroline Geers⁴  Karl M. Wissing¹  Emmanuel Letavernier⁵ 

[1] Nephrology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel;Urology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel;Microbiology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel;Pathology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel;Hôpital Tenon, Sorbonne Universités, Université Pierre et Marie Curie;Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S 1155

关键词: encrusted pyelitis;    Corynebacterium urealyticum;    urease-producing bacteria;    encrusted cystitis;    encrusted uropathy;   

DOI  :  10.3389/fmed.2020.609024

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Encrusted uropathy is a rare subacute to chronic inflammatory disorder caused by infection with urease-producing bacteria, mainly Corynebacterium urealyticum . The disorder is characterized by urothelial deposition of struvite and carbonated apatite, resulting in encrustations and ulceronecrotic inflammation of the urothelium and surrounding tissues. Most commonly, encrusted uropathy is encountered in patients with predisposing conditions. The disease remains underdiagnosed. High urinary pH and negative conventional urine cultures should raise suspicion of the diagnosis. Prognosis is dependent on timely diagnosis and treatment installment, which consists of urological removal of encrustations in combination with urinary acidification and long-term antibiotic therapy.

【 授权许可】

CC BY