Encrusted Uropathy: A Comprehensive Overview—To the Bottom of the Crust

Frontiers in Medicine

Deborah De Geyter¹  Karl M. Wissing²  Els Van de Perre²  Caroline Geers³  Emmanuel Letavernier⁴  Gina Reichman⁵ 

[1] Microbiology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;Nephrology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;Pathology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;Service des Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, Assistance Publique—Hôpitaux de Paris, Sorbonne Universités, Université Pierre et Marie Curie, Paris, France;Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S 1155, Paris, France;Urology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;

关键词: encrusted pyelitis;    Corynebacterium urealyticum;    urease-producing bacteria;    encrusted cystitis;    encrusted uropathy;   

DOI  :  10.3389/fmed.2020.609024

来源: Frontiers

【 摘 要 】

Encrusted uropathy is a rare subacute to chronic inflammatory disorder caused by infection with urease-producing bacteria, mainly Corynebacterium urealyticum. The disorder is characterized by urothelial deposition of struvite and carbonated apatite, resulting in encrustations and ulceronecrotic inflammation of the urothelium and surrounding tissues. Most commonly, encrusted uropathy is encountered in patients with predisposing conditions. The disease remains underdiagnosed. High urinary pH and negative conventional urine cultures should raise suspicion of the diagnosis. Prognosis is dependent on timely diagnosis and treatment installment, which consists of urological removal of encrustations in combination with urinary acidification and long-term antibiotic therapy.

【 授权许可】

CC BY