The Link Between Autonomic Nervous System and Rheumatoid Arthritis: From Bench to Bedside

Frontiers in Medicine

article

Francesca Ingegnoli¹  Massimiliano Buoli³  Flavia Antonucci⁵  Lavinia Agra Coletto¹  Cecilia Maria Esposito³  Roberto Caporali¹ 

[1] Division of Clinical Rheumatology, Gaetano Pini Hospital;Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano;Department of Neurosciences and Mental Health, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca'Granda Ospedale Maggiore Policlinico;Department of Pathophysiology and Transplantation, Università degli Studi di Milano;Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano

关键词: vagus nerve;    central nervous system;    autonomic nervous system;    mood disorder;    rheumatoid arthritis;    depression;    therapy;   

DOI  :  10.3389/fmed.2020.589079

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Neuronal stimulation is an emerging field of research focused on the management and treatment of various diseases through the reestablishment of physiological homeostasis. Electrical vagus nerve stimulation has recently been proposed as a revolutionary therapeutic option for rheumatoid arthritis (RA) in combination with or even as a replacement for conventional and biological drugs. In the past few years, disruption of the autonomic system has been linked to RA onset and activity. Novel research on the link between the autonomic nervous system and the immune system (immune-autonomics) has paved the way for the development of innovative RA management strategies. Clinical evidence supports this approach. Cardiovascular involvement, in terms of reduced baroreflex sensitivity and heart rate variability-derived indices, and mood disorders, common comorbidities in patients with RA, have been linked to autonomic nervous system dysfunction, which in turn is influenced by increased levels of circulating pro-inflammatory cytokines. This narrative review provides an overview of the autonomic nervous system and RA connection, discussing most of the common cardiac and mental health-related RA comorbidities and their potential relationships to systemic and joint inflammation.

【 授权许可】

CC BY