Neuroimmune Interaction in Inflammatory Diseases

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine

Review

Jerry Yu¹  Joshiah Gordon¹  Huafeng Li¹  Mary Proctor¹  Mohamed Saad¹  Juan Guardiola¹  Peyman Otmishi¹  Seraj El-Oshar¹ 

[1] Pulmonary and Critical Care, Department of Medicine, Ambulatory Care Building, 3rd floor University of Louisville, Louisville, KY 40292, U.S.A.;

关键词: vagus nerve;    sensory nerve;    inflammation;    immune;    autonomic nervous system;   

DOI  :  10.4137/CCRPM.S547

来源: Sage Journals

【 摘 要 】

The inflammatory response is modulated through interactions among the nervous, endocrine, and immune systems. Intercommunication between immune cells and the autonomic nervous system is a growing area of interest. Spatial and temporal information about inflammatory processes is relayed to the central nervous system (CNS) where neuroimmune modulation serves to control the extent and intensity of the inflammation. Over the past few decades, research has revealed various routes by which the nervous system and the immune system communicate. The CNS regulates the immune system via hormonal and neuronal pathways, including the sympathetic and parasympathetic nerves. The immune system signals the CNS through cytokines that act both centrally and peripherally. This review aims to introduce the concept of neuroimmune interaction and discuss its potential clinical application, in an attempt to broaden the awareness of this rapidly evolving area and open up new avenues that may aid in the treatment of inflammatory diseases.

【 授权许可】

CC BY   
© 2008 SAGE Publications.