When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension

Frontiers in Medicine

article

Aneel Bhagwani¹  A. A. Roger Thompson³  Laszlo Farkas¹ 

[1] Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart & Lung Research Institute, The Ohio State University, United States;Department of Physiology and Biophysics, Virginia Commonwealth University, United States;Department of Infection, Faculty of Medicine, Dentistry & Health, University of Sheffield, United Kingdom

关键词: toll-like receptors;    endothelial cells;    angiogenesis;    pulmonary hypertension;    immunology;   

DOI  :  10.3389/fmed.2020.00352

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Toll-like receptors serve a central role in innate immunity, but they can also modulate cell function in various non-immune cell types including endothelial cells. Endothelial cells are necessary for the organized function of the vascular system, and part of their fundamental role is also the regulation of immune function and inflammation. In this review, we summarize the current knowledge of how Toll-like receptors contribute to the immune and non-immune functions of the endothelial cells.

【 授权许可】

CC BY