Pre-existing Alloreactive T and B Cells and Their Possible Relevance for Pre-transplant Risk Estimation in Kidney Transplant Recipients

Frontiers in Medicine

article

Gonca E. Karahan¹  Sebastiaan Heidt¹ 

[1] Department of Immunohematology and Blood Transfusion, Leiden University Medical Center

关键词: HLA-specific memory;    alloantibodies;    alloimmune response;    T cell-mediated rejection (TCMR);    antibody-mediated rejection (ABMR);   

DOI  :  10.3389/fmed.2020.00340

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

In allogeneic transplantation, genetic disparities between patient and donor may lead to cellular and humoral immune responses mediated by both naïve and memory alloreactive cells of the adaptive immune system. This review will focus on alloreactive T and B cells with emphasis on the memory compartment, their role in relation to kidney rejection, and in vitro assays to detect these alloreactive cells. Finally, the potential additional value of utilizing donor-specific memory T and B cell assays supplementary to current routine pre-transplant risk assessment of kidney transplant recipients will be discussed.

【 授权许可】

CC BY