Frequency of class I anti-HLA alloantibodies in patients infected by HIV-1

Brazilian Archives of Biology and Technology

Elza Regina Manzolli Leite¹  Oswaldo Luiz Luz Lima²  Fábio Renato Manzolli Leite²  Paulo Inácio Da Costa¹ 

[1] ,Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Araraquara SP ,Brasil

关键词: AIDS;    HIV;    HLA antigens;    alloantibodies;   

DOI  :  10.1590/S1516-89132010000100012

来源: SciELO

【 摘 要 】

The aim of this study was to evaluate the presence of class I anti-HLA alloantibodies in patients infected by HIV-1 and relate it with the different clinical courses of the disease. Blood samples were collected in EDTA tubes from 145 individuals. HIV-1 infection was confirmed by ELISA test. The presence of class I anti-HLA alloantibodies and HLA allele's were determined. Clinical evolution was set as fast (<1 year between diagnostic and death), moderate (1-3 years) or slow (>3 years). Class I anti-HLA alloantibodies presence was lower in healthy individuals than in those infected by HIV-1 (4.2% against 32.4%). However, an equal distribution of these alloantibodies was found among the individuals infected, independent on the clinical evolution. Thus, class I anti-HLA alloantibodies was not a determinant factor for patient worsening.

【 授权许可】

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