Oral Probiotics Alleviate Intestinal Dysbacteriosis for People Receiving Bowel Preparation

Frontiers in Medicine

article

Xiaorong Deng¹  Huakai Tian¹  Rong Yang¹  Yiwen Han²  Kehong Wei²  Cihua Zheng¹  Zhaoxia Liu³  Tingtao Chen¹ 

[1] Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University;National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University;Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University

关键词: bowel preparation;    probiotics;    high-throughput sequencing;    Proteobacteria;    Firmicutes;    Bacteroidetes;   

DOI  :  10.3389/fmed.2020.00073

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Bowel preparation is necessary for successful colonoscopy, while it can seriously affect intestinal microbial composition and damage the intestinal mucosal barriers in humans. Methods: To figure out whether probiotics can sustain intestinal homeostasis and guard people's health, the probiotic drug of Bifidobacterium Tetragenous viable Bacteria Tablets (P group, n = 16) or placebo (C group, n = 16) was used for volunteers receiving bowel preparation, and high-throughput sequencing method was applied to monitor their intestinal microbial changes. Results: The present results suggested that bowel preparation obviously reduced the intestinal microbial diversity, while taking probiotics significantly restored it to normal level. In addition, probiotics sharply reduced the abundance of pathogenic Proteobacteria , and obviously lowered the ratio of Firmicutes/Bacteroidetes compared with control group at phylum level ( P < 0.05). And probiotics markedly decreased the abundance of pathogenic Acinetobacter and Streptococcus , while greatly enriched the relative abundance of beneficial bacteria Bacteroides, Roseburia, Faecalibacterium , and Parabacteroides at genus level ( P < 0.05). Conclusion: Probiotic drugs, e.g., Bifidobacterium Tetragenous viable Bacteria Tablets, can be used to restore intestinal dysbacteriosis caused by bowel preparation, and reduce side effects during colonoscopy.

【 授权许可】

CC BY