Immunotherapy Targeting Tumor-Associated Macrophages

Frontiers in Medicine

article

Yafei Liu¹  Rongsi Wang² 

[1] Department of Pharmacy, The Forth Affiliation Hospital of China Medical University;High School of East China Normal University

关键词: macrophage;    tumor microenvironment;    cancer;    immunotherapy;    polarization;   

DOI  :  10.3389/fmed.2020.583708

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Macrophages are phagocytic cells that play a broad role in maintaining body homeostasis and defense against foreign pathogens; whereas tumor-associated macrophages (TAMs) support tumor growth and metastasis by promoting cancer cell proliferation and invasion, immunosuppression, and angiogenesis, which is closely related to the poor prognosis in almost all solid tumors. Hence, deep-insight knowledge into TAMs can provide an opportunity to discover more effective strategies for cancer therapeutics. So far, a large number of therapeutic agents targeting TAMs are in clinical trials. In this review, we introduce an extensive overview about macrophages and macrophage-targeting agents.

【 授权许可】

CC BY