Various Uses of PD1/PD-L1 Inhibitor in Oncology: Opportunities and Challenges

Frontiers in Oncology

Guoqiang Sun¹  Zhitao Li¹  Ye Cheng¹  Guangshun Sun¹  Liangliang Wu¹  Chengyu Lv¹  Yichan Zhou²  WeiweiTang³  Yongxiang Xia³  Qian Wang⁴ 

[1] Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, China;Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany;

关键词: cancer;    PD-1/PD-L1 inhibitors;    drug combination therapy;    immunotherapy;    tumor microenvironment;   

DOI  :  10.3389/fonc.2021.771335

来源: DOAJ

【 摘 要 】

The occurrence and development of cancer are closely related to the immune escape of tumor cells and immune tolerance. Unlike previous surgical, chemotherapy, radiotherapy and targeted therapy, tumor immunotherapy is a therapeutic strategy that uses various means to stimulate and enhance the immune function of the body, and ultimately achieves the goal of controlling tumor cells.With the in-depth understanding of tumor immune escape mechanism and tumor microenvironment, and the in-depth study of tumor immunotherapy, immune checkpoint inhibitors represented by Programmed Death 1/Programmed cell Death-Ligand 1(PD-1/PD-L1) inhibitors are becoming increasingly significant in cancer medication treatment. employ a variety of ways to avoid detection by the immune system, a single strategy is not more effective in overcoming tumor immune evasion and metastasis. Combining different immune agents or other drugs can effectively address situations where immunotherapy is not efficacious, thereby increasing the chances of success and alternative access to alternative immunotherapy. Immune combination therapies for cancer have become a hot topic in cancer treatment today. In this paper, several combination therapeutic modalities of PD1/PD-L1 inhibitors are systematically reviewed. Finally, an analysis and outlook are provided in the context of the recent advances in combination therapy with PD1/PD-L1 inhibitors and the pressing issues in this field.

【 授权许可】

Unknown