Commentary: Peripheral Circulating Exosome-Mediated Delivery of miR-155 as a Novel Mechanism for Acute Lung Inflammation

Frontiers in Medicine

article

Lin Zhang¹  Heng Meng¹  Qing Geng¹ 

[1] Department of Thoracic Surgery, Renmin Hospital of Wuhan University

关键词: exosomes;    acute lung injury;    macrophages;    intercellular communication;    miRNAs;   

DOI  :  10.3389/fmed.2020.00507

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Acute lung injury (ALI) is a devastating respiratory disorder characterized by clinically significant hypoxemia, diffuse bilateral pulmonary infiltration, pulmonary edema, decrease in pulmonary compliance, and decrease in functional residual capacity (1). Macrophages, the cells that play a central role in the inflammatory microenvironment of ALI, have been shown to contribute significantly to the inflammatory process of this disease (1). Although the interactions between macrophages and other cells in the inflammatory responses of lung have been well-described previously, the function of exosomes as a mediator of signal transmission in ALI has not been fully elucidated. In a previous issue of Molecular Therapy, Jiang et al. described the serum exosomes derived from ALI mice serum that delivered miR-155 to naive mice or naive macrophages to induce inflammation (2). The communicational role of exosomes to carry proinflammatory signals and mediate inflammation was demonstrated by using the adoptively transfer method that involves transferring of immunoreactive molecules from donor to recipient, as was applied in previous research (3).

【 授权许可】

CC BY