Second Periprosthetic Joint Infection Caused by Streptococcus dysgalactiae : How Genomic Sequencing Can Help Defining the Best Therapeutic Strategy

Frontiers in Medicine

article

Truong-Thanh Pham¹  Vladimir Lazarevic³  Nadia Gaia³  Myriam Girard³  Abdessalam Cherkaoui⁴  Domizio Suva²  Jacques Schrenzel¹ 

[1] Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals;Division of Orthopedics and Trauma Surgery, Department of Surgery, Geneva University Hospitals;Genomic Research Laboratory, Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Geneva, Geneva University Hospitals;Bacteriology Laboratory, Department of Diagnostic, Geneva University Hospitals

关键词: periprosthetic joint infection;    PJI;    Streptococcus dysgalactiae;    next-generation sequencing;    NGS;   

DOI  :  10.3389/fmed.2020.00053

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Primary and revision arthroplasties are increasing worldwide, as are periprosthetic joint infections (PJI). The management of PJI requires surgery, the strategy of which is dictated by the acute or chronic nature of the infection, with an exchange of the implant in the event of a chronic PJI or in the case of recurrence with the same pathogen. We report the case of a 63-year-old man with two episodes of Streptococcus dysgalactiae subsp. equisimilis PJI within 9 months. Based on clinical suspicion of an haematogenous PJI, the patient was treated by DAIR (debridement, antibiotics, implant retention), while genomic sequencing revealed two different strains, confirming our hypothesis that no additional surgery was needed. Hence, we report a case where genomic analysis was decisive for the decision of the best therapeutic strategy.

【 授权许可】

CC BY