Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study

Frontiers in Medicine

article

Hsin-Hua Chen¹  Hsian-Min Chen¹  Ching-Heng Lin¹  Kuo-Tung Tang²  Der-Yuan Chen^1,11  James Cheng-Chung Wei^1,14  Wen-Cheng Chao⁵ 

[1] Department of Medical Research, Taichung Veterans General Hospital;Division of Allergy, Department of Internal Medicine, Taichung Veterans General Hospital;Institute of Biomedical Science and Rong Hsing Research Centre for Translational Medicine, Chung Hsing University;Department of Industrial Engineering and Enterprise Information, Tunghai University;Big Data Center, Chung Hsing University;Department of Medical Research, Center for Quantitative Imaging in Medicine, Taichung Veterans General Hospital;Department of Computer Science and Information Engineering, National United University;Department of Healthcare Management, National Taipei University of Nursing and Health Sciences;Department of Public Health, College of Medicine, Fu Jen Catholic University;Faculty of Medicine, National Yang-Ming University;Rheumatology and Immunology Center, China Medical University Hospital;School of Medicine, China Medical University;Translational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital;Division of Allergy, Chung Shan Medical University Hospital;Institute of Medicine, Chung Shan Medical University;Institute of Integrative Medicine, China Medical University;Department of Critical Care Medicine, Taichung Veterans General Hospital;Department of Computer Science, Tunghai University;Department of Automatic Control Engineering, College of Information and Electrical Engineering, Feng Chia University

关键词: Sjögren's syndrome;    mammary gland;    mastitis;    fibrocystic breast disease;    epidemiology;   

DOI  :  10.3389/fmed.2021.704593

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective: Primary Sjögren's syndrome (pSS) is characterized by exocrine glandular inflammation; however, the association between preceding mammary-gland-inflammation-related diseases and newly diagnosed pSS remains unexplored. Methods: We used the 2003–2013 data retrieved from Taiwan's National Health Insurance Research Database (NHIRD) to conduct the present population-based study. We identified newly diagnosed pSS female patients during the 2001–2013 period, as well as age-matched (1:20) and propensity-score-matched (1:2) non-SS individuals (as controls). We explored the associations between pSS and a history of mastitis and fibrocystic breast disease by determining adjusted odds ratios (aORs) with 95% confidence intervals (CIs) using a conditional logistical regression analysis after controlling for potential confounders. Results: We identified 9,665 patients with pSS and 193,300 age-matched non-SS controls, as well as 9,155 SS cases and 18,310 propensity-score-matched non-SS controls. We found that fibrocystic breast disease (aOR, 1.75; 95% CI, 1.63–1.88) were independently associated with incident SS, whereas mastitis and childbirth-associated breast infections were not associated with incident SS. We also found positive associations between SS and previously reported SS-associated diseases, including cardiovascular diseases, thyroid diseases, pancreatitis, bronchiectasis, infectious diseases, osteoporosis, and ankylosing spondylitis. In the propensity-score-matched populations, the associations between pSS and fibrocystic breast disease (aOR, 1.74; 95% CI, 1.58–1.91) remained consistent. Conclusion: The present population-based study revealed a previously unexplored association between pSS and history of fibrocystic breast disease, and the finding highlights the need to survey pSS in patients with mammary-gland-inflammation-associated diseases.

【 授权许可】

CC BY