Is 70 Zn(d,x) 67 Cu the Best Way to Produce 67 Cu for Medical Applications?

Frontiers in Medicine

article

Etienne Nigron¹  Arnaud Guertin¹  Ferid Haddad¹  Thomas Sounalet¹ 

[1] Laboratory SUBATECH, Université de Nantes;GIP ARRONAX

关键词: 67 Cu;    production;    theranostic;    cross section;    deuteron reactions;    accelerators;   

DOI  :  10.3389/fmed.2021.674617

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The pair of copper radionuclides 64 Cu/ 67 Cu (T 1/2 = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. An analysis of the different production routes of 67 Cu with charged particles was performed and the reaction 70 Zn(d,x) route was identified as a promising one. It may allow the production of 67 Cu without 64 Cu. The production cross section has been measured up to 28.7 MeV. Measurements were done using the well-known stacked-foils technique using 97.5% enriched 70 Zn homemade electroplated targets. These measurements complement at higher incident energies the only set of data available in nuclear databases. The results show that using a 26 MeV deuteron beam and a highly enriched 70 Zn target, it is possible to produce high purity 67 Cu comparable to that obtained using photoproduction. This production route can be of interest for future linear accelerators under development where mA deuteron beams can be available if adequate targetry is developed.

【 授权许可】

CC BY