Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes

Frontiers in Medicine

article

Claudia Zeidler¹  Sonja Ständer¹ 

[1] Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster

关键词: prurigo nodularis;    pruritus;    burden;    quality of life;    itch characteristics;   

DOI  :  10.3389/fmed.2021.649332

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Chronic prurigo is a debilitating skin disease characterized by the presence of chronic pruritus and scratching-related pruriginous lesions. The pruriginous lesions can differ in their clinics what has recently been categorized into different clinical phenotypes. The most common one is chronic nodular prurigo (syn. prurigo nodularis); other phenotypes are papular, plaque, umbilicated, and linear prurigo. A comparison between these phenotypes regarding similarities and differences has not yet been performed. In this explorative analysis, itch characteristics, scratching behavior, and disease burden of the nodular, papular, plaque, and umbilicated prurigo were investigated in 1,128 patients. Patients with nodular and plaque prurigo were younger than patients with papular and umbilicated prurigo. The shortest duration of the underlying pruritus was found in papular and umbilicated prurigo, the longest in plaque prurigo. Itch intensity, impairment of sleep, mood and the quality of life did not differ. These findings confirm that the clinical phenotypes of chronic prurigo belong to a spectrum of one disease with similar disease characteristics and can be categorized under the umbrella term of chronic prurigo. Future clinical trials should include all phenotypes of chronic prurigo.

【 授权许可】

CC BY