A Retrospective Study of Lung Transplantation in Patients With Lymphangioleiomyomatosis: Challenges and Outcomes

Frontiers in Medicine

article

Ji Zhang¹  Kai-Feng Xu²  Wenhui Chen³  Jingyu Chen¹  Dong Liu¹  Bingqing Yue¹  Le Ban¹  Min Zhou¹  Hongmei Wang¹  Jian Lv¹  Bo Wu¹  Zhenguo Zhai⁴ 

[1] Wuxi Lung Transplant Center, Wuxi People's Hospital Affiliated to Nanjing Medical University;Department of Respiratory Medicine, Peking Union Medical College Hospital;Department of Lung Transplantation, Center for Lung Transplantation, Center for Respiratory Diseases, China-Japan Friendship Hospital;Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital;National Clinical Research Center for Respiratory Diseases, Peking University Health Science Center

关键词: lymphangioleiomyomatosis;    lung transplantation;    sirolimus;    infection;    anastomotic complication;   

DOI  :  10.3389/fmed.2021.584826

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Lymphangioleiomyomatosis (LAM) is a rare systemic disease that generally leads to a progressive decline in pulmonary function. Experience, especially from the Asian population, including combined drug therapy before and after lung transplantation (LT) in LAM, is still limited. This study aimed to summarize the clinical data from patients with pulmonary LAM who underwent LT at centers in China. Methods: A retrospective review of all patients with LAM undergoing LT at the two largest centers in China between 2010 and 2018 was conducted. Pre- and posttransplant data were assessed and analyzed. Results: Overall, 25 patients with LAM underwent bilateral LT. The mean age was 35.0 ± 8.6 years at diagnosis and 36.8 ± 9.3 years at the time of transplant. Before LT, only six patients could complete pulmonary function test; the reachable mean forced expiratory volume in one second (FEV 1 ) before LT was 15.9 ± 6.9%. Twenty-one patients (84%) had a recurrent pneumothorax, four (16.0%) of which required pleurodesis. Eight patients (32%) were treated with sirolimus pretransplant for 3.9 years (1–9 years). The average intra-surgery bleeding volume was 1,280 ± 730 ml in need of a transfusion of 1,316 ± 874 ml due to moderate-to-severe adhesion and pretransplant pleurodesis. The causes of death of four patients (16%) included primary graft dysfunction, bronchial dehiscence with long-term use of sirolimus, and uncontrollable infections. The median follow-up time from LT was 41.1 ± 25.0 months. Conclusions: LT for LAM patients from the Asian population has been reinforced from the data that we presented. Peri-transplantation use of sirolimus and LAM-related complications should be further defined and under constant surveillance.

【 授权许可】

CC BY