Editorial: Inflammation and Biomarkers in Osteoarthritis

Frontiers in Medicine

article

Ali Mobasheri¹  João Eurico Fonseca⁶  Oreste Gualillo⁸  Yves Henrotin⁹  Raquel Largo^1,11  Gabriel Herrero-Beaumont^1,11  Francisco Airton Castro Rocha^1,12 

[1] Research Unit of Medical Imaging, Faculty of Medicine, University of Oulu;Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine;Departments of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht;Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University;World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, University of Liège;Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa;Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisbon Academic Medical Centre;SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital;MusculoSKeletal Innovative Research Lab (mSKIL), Department of Motricity Sciences, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège;Physical Therapy and Rehabilitation Department, Princess Paola Hospital;Bone and Joint Research Unit, Rheumatology Department;Department of Internal Medicine, Faculdade de Medicina da Universidade Federal do Ceará

关键词: osteoarthritis;    biomarkers;    cartilage;    synovium;    inflammation;   

DOI  :  10.3389/fmed.2021.727700

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Osteoarthritis (OA) is the most common form of arthritis affecting more than 500 million people globally (1). It accounts for more pain and functional disability than any other musculoskeletal disease and is an important source of high societal and economic costs (2). Although the pathophysiology of OA is poorly understood (3), the risk factors associated with disease development are well-established. They include age (4), obesity (5), sex (6), previous incidence of joint injuries (7, 8), meniscal damage (9), joint instability (10), malalignment (11), genetics (12), bone shape (including anatomical deformities) (13), muscle weakness and sarcopenia (14), and metabolic disease (15–17). Although OA can affect any synovial joint, including joints in the hand, according to studies on the global burden of disease in 2010 (18) and 2017 (19), knee OA represents the greatest societal burden.

【 授权许可】

CC BY