Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens

Frontiers in Medicine

article

Zhonghui Ma¹  Su Yan³  Haoxin Dong¹  Huifen Wang²  Yonggang Luo⁵  Xi Wang¹ 

[1] Department of Stomatology, The First Affiliated Hospital of Zhengzhou University;Precision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University;Health Management Center, The First Affiliated Hospital of Zhengzhou University;Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University;Department of Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University

关键词: brain abscesses;    oral microbiome;    gram stain;    metagenomics next-generation sequencing;    precision treatment;   

DOI  :  10.3389/fmed.2021.644130

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Brain abscesses are associated with an increased long-term risk of new seizures and increased mortality within several years after infection. Common microorganisms that cause brain abscesses include bacteria, fungi, and mycoplasma. We report a 75-year-old man with a brain abscess caused by Prevotella denticola , an oral pathogen. Based on the clinical condition, we suspected that the patient had a blood-borne brain abscess, and he received antibiotics and systemic supportive treatment. The patient developed shock for the second time after negative Gram-staining results. Metagenomics next-generation sequencing showed one strain from the oral microbiome, confirming our hypothesis, and targeted antibiotic treatment was administered quickly. Thus, we report a case in which genomic analysis was the critical factor in determining the best antimicrobial therapy for administration.

【 授权许可】

CC BY