Frontiers in Medicine | |
Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens | |
Yonggang Luo1  Xi Wang2  Zhonghui Ma2  Haoxin Dong2  Huifen Wang3  Su Yan4  | |
[1] Department of Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Precision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Precision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Precision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Health Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; | |
关键词: brain abscesses; oral microbiome; gram stain; metagenomics next-generation sequencing; precision treatment; | |
DOI : 10.3389/fmed.2021.644130 | |
来源: Frontiers | |
【 摘 要 】
Brain abscesses are associated with an increased long-term risk of new seizures and increased mortality within several years after infection. Common microorganisms that cause brain abscesses include bacteria, fungi, and mycoplasma. We report a 75-year-old man with a brain abscess caused by Prevotella denticola, an oral pathogen. Based on the clinical condition, we suspected that the patient had a blood-borne brain abscess, and he received antibiotics and systemic supportive treatment. The patient developed shock for the second time after negative Gram-staining results. Metagenomics next-generation sequencing showed one strain from the oral microbiome, confirming our hypothesis, and targeted antibiotic treatment was administered quickly. Thus, we report a case in which genomic analysis was the critical factor in determining the best antimicrobial therapy for administration.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202107160612321ZK.pdf | 466KB | download |