A Little Experience Goes a Long Way: Chlormethine/Mechlorethamine Treatment Duration as a Function of Clinician-Level Patient Volume for Mycosis Fungoides Cutaneous T-Cell Lymphoma (MF-CTCL)—A Retrospective Cohort Study

Frontiers in Medicine

article

Christiane Querfeld¹  Theresa Pacheco²  Bradley Haverkos³  Gary Binder⁴  James Angello⁴  Brian Poligone⁵ 

[1] City of Hope Comprehensive Cancer Center, United States;Division of Dermatology, University of Colorado, United States;Division of Hematology, University of Colorado, United States;Helsinn Therapeutics US Inc., United States;Rochester Skin Lymphoma Medical Group, United States

关键词: cutaneous T-cell lymphoma;    chlormethine gel;    mechlorethamine;    dermatitis;    patient volume;    treatment outcomes;    mycosis fungoides;   

DOI  :  10.3389/fmed.2021.679294

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Topical chlormethine yields high response rates in mycosis fungoides cutaneous T-cell lymphoma with early discontinuation often attributed to skin reactions. We evaluated over 4,000 patients and found an association of clinician case volume with treatment duration and early discontinuation of chlormethine gel. The minority of clinicians with high patient volume markedly outperformed clinicians with only few patients on both outcome parameters, yet case volume as low as five patients seemed to mark a threshold for avoiding early discontinuation of treatment regimen.

【 授权许可】

CC BY