Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma

Toxins

Andreas Willerslev-Olsen⁵  Thorbjørn Krejsgaard⁵  Lise M. Lindahl⁴  Charlotte Menne Bonefeld⁵  Mariusz A. Wasik²  Sergei B. Koralov¹  Carsten Geisler⁵  Mogens Kilian³  Lars Iversen⁴  Anders Woetmann⁵ 

[1] Department of Pathology, NYU Langone Medical Center, New York, NY 10016, USA; E-Mail:;Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; E-Mail:;Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark; E-Mail:;Department of Dermatology, Aarhus University Hospital, Aarhus 8000, Denmark; E-Mails:;Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark; E-Mails:

关键词: cutaneous T-cell lymphoma;    infections;    Staphylococcus aureus;    enterotoxins;    superantigens;   

DOI  :  10.3390/toxins5081402

来源: mdpi

【 摘 要 】

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.