A Randomized Clinical Trial Comparing Three Different Exercise Strategies for Optimizing Aerobic Capacity and Skeletal Muscle Performance in Older Adults: Protocol for the DART Study

Frontiers in Medicine

article

Dallin Tavoian¹  David W. Russ²  Timothy D. Law¹  Janet E. Simon³  Paul J. Chase⁴  Emily Hill Guseman⁵  Brian C. Clark¹ 

[1] Ohio Musculoskeletal and Neurological Institute, Ohio University, United States;Laboratory for Integrative Muscle Biology, Division of Physical Therapy, Ohio University, United States;Division of Athletic Training, School of Applied Health Sciences and Wellness, Ohio University, United States;Division of Exercise Physiology, School of Applied Health Sciences and Wellness, Ohio University, United States;Diabetes Institute, Ohio University, United States;Department of Family Medicine, Heritage College of Osteopathic Medicine, Ohio University, United States;Department of Biomedical Sciences, Ohio University, United States

关键词: aging;    exercise;    intervals;    resistance;    aerobic;    power;    VO 2;    muscle;   

DOI  :  10.3389/fmed.2019.00236

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Age-related declines in physical function lead to decreased independence and higher healthcare costs. Individuals who meet the endurance and resistance exercise recommendations can improve their physical function and overall fitness, even into their ninth decade. However, most older adults do not exercise regularly, and the majority of those who do only perform one type of exercise, and in doing so are not getting the benefits of endurance or resistance exercise. Herein we present the study protocol for a randomized clinical trial that will investigate the potential for high-intensity interval training (HIIT) to improve maximal oxygen consumption, muscular power, and muscle volume (primary outcomes), as well as body composition, 6-min walk distance, and muscular strength and endurance (secondary outcomes). Methods and Analysis: This is a single-site, single-blinded, randomized clinical trial. A minimum of 24 and maximum of 30 subjects aged 60–75 that are generally healthy but insufficiently active will be randomized. After completion of baseline assessments, participants will be randomized in a 1:1:1 ratio to participate in one of three 12-week exercise programs: stationary bicycle HIIT, stationary bicycle moderate-intensity continuous training (MICT), or resistance training. Repeat assessments will be taken immediately post intervention. Discussion: This study will examine the potential for stationary bicycle HIIT to result in both cardiorespiratory and muscular adaptations in older adults. The results will provide important insights into the effectiveness of interval training, and potentially support a shift from volume-driven to intensity-driven exercise strategies for older adults. Clinical Trial Registration: This trial is registered with ClinicalTrials.gov (registration number: {"type":"clinical-trial","attrs":{"text":"NCT03978572","term_id":"NCT03978572"}} NCT03978572 , date of registration June 7, 2019).

【 授权许可】

CC BY