Spirometry in Central Asian Lowlanders and Highlanders, a Population Based Study

Frontiers in Medicine

article

Stefanie Ulrich¹  Michael Furian¹  Bermet Estebesova²  Nurgul Toktogulova³  Gulnara Beishekeeva³  Silvia Ulrich¹  Peter G. J. Burney⁴  Talant M. Sooronbaev²  Konrad E. Bloch¹ 

[1] Department of Respiratory Medicine, University Hospital Zurich;Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine;Therapy 1 Department, Medical Faculty, Kyrgyz-Russian Slavic University;Population Health and Occupational Disease, National Heart and Lung Institute & MRC-PHE Centre for Environment and Health, Imperial College London, United Kingdom

关键词: spirometry;    altitude;    lung function;    Central Asian;    highlanders;   

DOI  :  10.3389/fmed.2019.00308

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Introduction: The purpose of the study was to establish spirometric reference values for a Central Asian population of highlanders and lowlanders. Methods: Spirometries from a population-based cross-sectional study performed in 2013 in rural areas of Kyrgyzstan were analyzed. Using multivariable linear regression, Global Lung Function Initiative (GLI) equations were fitted separately for men and women, and altitude of residence (700–800 m, 1,900–2,800 m) to data from healthy, never-smoking Kyrgyz adults. The general GLI equation was applied: Predicted value = e a 0 + a 1 ×  ln ( Height ) + a 2 ×  ln ( Age ) + b 1 ×  ln ( Age 100 ) + b 2 ×  ln ( Age 100 ) 2 + b 3 ×  ln ( Age 100 ) 3              + b 4 ×  ln ( Age 100 ) 4 + b 5 ×  ln ( Age 100 ) 5.

【 授权许可】

CC BY