The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

Frontiers in Medicine

article

Lian Wang¹  Yu-Jia Wang²  Dan Hao¹  Xiang Wen¹  Dan Du¹  Gu He¹  Xian Jiang¹ 

[1] Department of Dermatology, West China Hospital, Sichuan University;State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy

关键词: mast cell;    rosacea;    pathophysiology;    treatment;    dermatology;   

DOI  :  10.3389/fmed.2019.00324

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea. In this review article, we describe recent advances of skin mast cells in the development of rosacea. These studies suggested that mast cells can be an important immune cell that connected innate immunity, nerves, and blood vessels in the development of rosacea. Moreover, we review the inhibition of mast cells for the potential treatment of rosacea.

【 授权许可】

CC BY