The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

Frontiers in Medicine

卷:6

Lian Wang¹  Xiang Wen¹  Xian Jiang¹  Dan Hao¹  Dan Du¹  Yu-Jia Wang²  Gu He² 

[1] Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China;

[2] State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China;

关键词: mast cell;    rosacea;    pathophysiology;    treatment;    dermatology;   

DOI  :  10.3389/fmed.2019.00324

来源: DOAJ

【 摘 要 】

Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea. In this review article, we describe recent advances of skin mast cells in the development of rosacea. These studies suggested that mast cells can be an important immune cell that connected innate immunity, nerves, and blood vessels in the development of rosacea. Moreover, we review the inhibition of mast cells for the potential treatment of rosacea.

【 授权许可】

Unknown